The region of Asia is preparing for the possibility of a second term for President Donald Trump, which is expected to bring uncertainty to the region’s relationship with the United States. Trump’s first term saw a shift in US foreign policy, including a trade war with China and engagement with diplomatically isolated leaders in Asia. If re-elected, Trump has promised to implement an even more aggressive “America first” agenda, including imposing tariffs on Chinese imports and other foreign goods. This has raised concerns among leaders in Asia, where many economies are heavily dependent on trade. Trump’s policies could have a significant impact on the region’s economy, with estimates suggesting a decline in exports and imports. Asian business leaders are advised to start planning for potential outcomes and managing their exposure to China. Trump’s ambivalence towards traditional alliances and partnerships, as well as his approach to defending partners from aggression, has also raised concerns in the region. Countries like South Korea and Japan may need to adjust their foreign policy to navigate the uncertainties of a second Trump presidency. Additionally, Trump’s isolationist approach could give China a diplomatic advantage in the region, as seen in the success of Beijing’s Regional Comprehensive Economic Partnership during Trump’s first term. Overall, the prospect of a second Trump presidency has created uncertainty and raised questions about the future of US-Asia relations.